Home[English] » Undergraduate Studies » Biochemistry II

Biochemistry ΙI

AIM

To familiarize students with the function of cell at the molecular level. The understanding of the flow of genetic information in physiological conditions and how this can be modified by signals acting at the DNA level.  

CONTENT OF THE COURSE

Τhe flow of genetic information (chromosomes, replication, transcription, translation, post translational modifications, protein targeting). Regulation of gene expression in prokaryotes (operons) and eukaryotes. DNA damage. Mutations. Mechanisms of DNA repair (base excision repair, nucleotide excision repair, mismatch repair MMR). Oncogenes and anti-oncogenes. Carcinogenesis.
Biochemistry of hormones (structure, biosynthesis, catabolism, general mechanism of action, regulation of secretion, actions in target – tissues). Integration of metabolism. Regulation of genetic programs. Regulation of gene expression in eukaryotes (DNA regulatory elements/ response elements/ types of transcription factors/ topography of transcription factors and activation of genetic programs for tissue differentiation). Regulation of transcription factors’ activity by external signals (signal transduction, examples from specific pathologies )

EDUCATIONAL METHODS

  •  Lectures.

SUCCESSFUL COMPLETION

  • Successful final examinations.