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Nikolaos Nikitakis

Associate Professor


Phone: (+30) 210-746-1003
Email: nnikitakis[at]dent.uoa[dot]gr

Mailing Address:
2 Thivon Str, 115 27, Goudi, Athens, Greece

Ελληνική Έκδοση English Version

Education / Qualifications

  • DDS, School of Dentistry, National and Kapodistrian University of Athens, Greece, 1996
  • Certificate in Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore, USA, 2001
  • Fellowship Certificate, American Academy of Oral and Maxillofacial Pathology, 2001
  • Ph.D in Oral and Experimental Pathology, Dental School, University of Maryland, Baltimore, USA, 2002
  • Diploma, American Board of Oral and Maxillofacial Pathology, 2003
  • Fellowship Certificate, American Academy of Oral Medicine, 2004
  • MD, School of Medicine, National and Kapodistrian University of Athens, Greece, 2012

Academic and professional positions held

  • Graduate Research Assistant, Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore, USA, 1999-2002
  • Assistant Professor (Full Time, Tenure Track), Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, USA, 2002-2006
  • Director, Postgraduate Residency Program in Oral and Maxillofacial Pathology  and PhD Program in Oral and Experimental Pathology, Dental School, University of Maryland, Baltimore, USA, 2004-2006
  • Adjunct Associate Professor, Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, USA, 2007-2008
  • Assistant Professor, Department of Oral Pathology and Surgery, School of Dentistry, National and Kapodistrian University of Athens, Greece, 2006-date

Academic and professional responsibilities

  • Supervisor in 1 postgraduate certificate thesis (completed) and 1 PhD dissertation (completed), member in 3 PhD advisory committees (completed), Postgraduate Program, Dental School, University of Maryland, Baltimore
  • Supervisor in 5 M.Sc. theses (completed) and 1 PhD dissertation (active), member in 7 PhD advisory committees (active), Postgraduate Program, Dental School, University of Athens
  • Member of the Infection Control and Biohazard Committee (2002-2003), Quality Assurance/Biosafety Committee (2003-2006), Faculty Council (2003-2006), Advanced Dental and Graduate Education Committee (2004-2006), Faculty Senate (2005-2006), Scientific Review Committee (2006), Dental School, University of Maryland, Baltimore
  • Member of General Assembly (2007-2008, 2009-2010, 2013-), Postgraduate Curriculum Committee (2007-2008, 2009-2010), Committee for the selection of postgraduate students in Oral Pathology and Medicine (2007-), Ethics and Research Committee (2011-), Dental School, Univeristy of Athens, Greece
  • Member of the Board of Executives (2007-) and Treasurer (2009-), Hellenic Society of Oral Medicine and Pathology
  • Member of the Scientific Committee, Athens Dental Society (2008-)
  • Member of the Organizing Committee of the 1st and 2nd Panhellenic Scientific meeting of Oral Medicine and Pathology (2009, 2012), Member of the Scientific Committee, 10th Biennial European Association of Oral Medicine (EAOM) Conference (2010), Member of the Organizing Committee, 11th Biennial European Association of Oral Medicine (EAOM) Congress (2012)
  • Member of the Editorial Board in 5 scientific journals [Journal of Oral and Maxillofacial Surgery (2005-2010), Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology (2006-), Oral Diseases (2008-2011), Archives of Hellenic Medicine (2008-), Journal of Oral and Maxillofacial Research (2011-)]
  • Reviewer of scientific manuscripts in 15 scientific journals 
  • Μember of the referee network, Research Grants Council of Hong Cong (2007-)

Research Grants and Contracts

Principal Investigator

  • Silencing of suppressors of cytokine signaling (SOCS) in oral squamous cell carcinoma» [Designated Research Initiative Funds, Dental School, University of Maryland, Baltimore, 1/2003-12/2003]
  • Stat3-mediated downregulation of Survivin expression by COX inhibitors in oral squamous cell carcinoma» [The University of Maryland Greenebaum Cancer Center Pilot Grant Program, 10/2004-4/2006]
  • Investigation of expression, activation and interaction of signaling pathways MAPK and STAT3 in oral squamous cell carcinoma [ELKE, National and Kapodistrian University of Athens, 2008-2009]

Co-investigator

  • A novel serpin inhibitor of oral squamous carcinoma invasion [National Institute of Health/National Cancer Institute, USA, R01 DE12606, 1999-2008]
  • Cell marker and homing target for oral squamous carcinoma [National Institute of Health/National Cancer Institute, USA, R01 DE13118, 2000-2005]
  • Prognostic Markers in Trials for Head and Neck Cancer [National Institute of Health/National Cancer Institute, USA, R01 CA90328, 2005-2009]
  • The oncogenic role of STAT3 in oral squamous cell carcinoma [Irakleitos ΙΙ, ELKE, National and Kapodistrian University of Athens, 2011-2013]

Awards and Honours

  • NATO assistantship for postgraduate studies in Medical Sciences in USA, 1998-1999
  • Graduate Merit Award, Dental School, University of Maryland, Baltimore, USA, 1999
  • Member of the Honor Society of Phi Kappa Phi in recognition of academic excellence, 2002
  • Trainee award, Sixth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, McLean, Virginia, October 9-13, 2002
  • Single Primary Investigator Designated Research Initiative Funds (DRIF) Award, Dental School, University of Maryland, Baltimore, 2003
  • Basic science award (Postgraduate student Hessam Siavash), Student Poster-Table Clinic Program, Student/Faculty Scholarship Day, Dental School, University of Maryland, Baltimore, MD, April 24, 2003
  • New Investigator Award, The University of Maryland Greenebaum Cancer Center Pilot Grant Program, 2004
  • Best Resident Basic Science Paper (Postgraduate student Hessam Siavash), 6th International Conference on Head and Neck Cancer, August 7-11, 2004, Washington, DC
  • Gorlin Award (Postgraduate student Mark Scheper), American Academy of Oral and Maxillofacial Pathology, 60th Annual Meeting and Continuing Education Program, San Antonio, TX, April 22–26, 2006
  • Hamilton B.G. Robinson Prize,  for the best Oral and Maxillofacial Pathology scientific paper published in Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 2009
  • Young Scientist/Clinician Awards (Postgraduate student Konstantinos Katoumas), 10th Biennial Conference of European Association of Oral Medicine, London, September 21-25, 2010
  • Waldron Award, 65th Annual Meeting and Continuing Education Program of American Academy of Oral and Maxillofacial Pathology, San Juan, Puerto Rico, April 28–May 3, 2011

Memberships

  • International Association for Dental Research (IADR) (2000-2006)
  • American Association for Dental Research (AADR) (2000-2006)
  • The Oral Medicine and Pathology Group, International Association for Dental Research (IADR) (2002-2006)
  • American Academy of Oral and Maxillofacial Pathology (AAOMP) (Member: 2000-, Fellow: 2001-)
  • American Academy of Oral Medicine (AAOM) (Μember: 2002-, Fellow: 2004-)
  • European Association of Oral Medicine (EAOM) (2002-)
  • North American Society for Head and Neck Pathology (NASHNP) (2002-)
  • American Association for Cancer Research (AACR) (2003-2006)
  • American Board of Oral and Maxillofacial Pathology (ABOMP) (2003-)
  • American Dental Education Association (ADEA) (2004-)
  • Hellenic Association of Supportive Care of the Oral Cavity in Cancer (HASCOCC) (Founding Member: 2005-)
  • Hellenic Society of Oral Medicine and Pathology (2007-)
  • Hellenic Association for Molecular Cancer Research (HAMCR) (Founding Member: 2008-)
  • Hellenic Society of Odontostomatological Research (2008-)

Research Theses – Books

  • Antineoplastic effect of NSAID sulindac on human oral squamous cell carcinoma cells: the role of cyclooxygenase-2 (COX-2), peroxisome proliferator-activated receptor gamma (PPARg), and signal transduser and activator of transcription 3 (Stat3). PhD Dissertation, Baltimore, USA 2002
  • Assessment of the activation of DNA repair mechanisms in oral potentially malignant lesions. Research Monograph, Athens 2012

Selected publications in scientific journals

  • Schumaker L, Nikitakis N, Goloubeva O, Tan M, Taylor R, Cullen KJ. Elevated expression of glutathione S-transferase pi and p53 confers poor prognosis in head and neck cancer patients treated with chemoradiotherapy but not radiotherapy alone. Clin Cancer Res. 2008;14:5877-83.
  • Nikitakis NG, Scheper MA, Papanikolaou VS, Sauk JJ. The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:826-36.
  • Nikitakis NG, Scheper MA, Papanikolaou VS, Sklavounou A, Sauk JJ. Immunohistochemical expression of the oncogenic molecules active Stat3 and survivin in benign and malignant salivary gland tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:837-43.
  • Cullen KJ, Schumaker L, Nikitakis N, Sarlis NJ, Tan M, Goloubeva O, Haddad RI, Posner MR. beta-Tubulin-II expression strongly predicts outcome in patients receiving induction chemotherapy for locally advanced squamous carcinoma of the head and neck: a companion analysis of the TAX 324 Trial. J Clin Oncol. 2009;27:6222-8.
  • Sauk JJ, Nikitakis NG, Scheper MA. Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:68-78.
  • Wen J, Nikitakis NG, Chaisuparat R, Greenwell-Wild T, Gliozzi M, Jin W, Adli A, Moutsopoulos N, Wu T, Warburton G, Wahl SM. Secretory Leukocyte Protease Inhibitor (SLPI) Expression and Tumor Invasion in Oral Squamous Cell Carcinoma. Am J Pathol. 2011;178:2866-78.
  • Wu Y, Posner MR, Schumaker LM, Nikitakis N, Goloubeva O, Tan M, Lu C, Iqbal S, Lorch J, Sarlis NJ, Haddad RI, Cullen KJ. Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer: An analysis of the TAX 324 trial. Cancer. 2012;118:1811-7.
  • Nikitakis NG, Polymeri A , Polymeris A , Sklavounou A . Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review. Head Neck Pathol. 2012;6:216-23.
  • Piperi E , Tosios KI , Nikitakis NG, Kyriakopoulos VF , Tzerbos F , Koutlas IG , Sklavounou A . Well-Differentiated Liposarcoma/Atypical Lipomatous Tumor of the Oral Cavity: Report of Three Cases and Review of the Literature. Head Neck Pathol. 2012;6:354-63.
  • Nikitakis NG, Polyzois G, Katoumas K, Titsinides S, Zolota V, Sklavounou A, Papadas T. Extranodal nasal type NK/T cell lymphoma of the palate and paranasal sinuses. Am J Case Rep. 2012:13;79-85.
  • Karathanasi V, Tosios KI, Nikitakis NG, Piperi E, Koutlas I, Trimis G, Sklavounou A.TGF-β1, Smad-2/-3, Smad-1/-5/-8, and Smad-4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study. J Oral Pathol Med. 2012 Nov 15. doi: 10.1111/jop.12016. [Epub ahead of print]

Areas of scientific interest

  • Oral Squamous Cell Carcinoma and Potentially Malignant Disorders: Immunohistochemical and molecular markers; cancer cell proliferation and apoptosis; cell signaling pathways; angiogenesis; novel antineoplastic strategies and molecular targets
  • Salivary Gland, Soft Tissue and Odontogenic Tumors: Clinicopathologic characterization and immunohistochemical analysis
  • Non-neoplastic diseases and conditions of the oral and maxillofacial region: diagnosis and management (e.g. immunologically-mediated diseases, oral manifestations of systemic diseases, burning mouth syndrome)

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