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Nikolaos Nikitakis

Associate Professor


Phone: (+30) 210-746-1003
Email: nnikitakis[at]dent.uoa[dot]gr

Mailing Address:
2 Thivon Str, 115 27, Goudi, Athens, Greece

Ελληνική Έκδοση English Version

Education / Qualifications

  • DDS, School of Dentistry, National and Kapodistrian University of Athens, Greece, 1996
  • Certificate in Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore, USA, 2001
  • Fellowship Certificate, American Academy of Oral and Maxillofacial Pathology, 2001
  • PhD in Oral and Experimental Pathology, Dental School, University of Maryland, Baltimore, USA, 2002
  • Diploma, American Board of Oral and Maxillofacial Pathology, 2003
  • Fellowship Certificate, American Academy of Oral Medicine, 2004
  • MD, School of Medicine, National and Kapodistrian University of Athens, Greece, 2012

Academic Positions

  • 1999-2002: Graduate Research Assistant, Department of Oral and Maxillofacial Pathology, Dental School, University of Maryland, Baltimore, USA
  • 2002-2006: Assistant Professor (Full Time, Tenure Track), Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, USA
  • 2004-2006: Director, Postgraduate Residency Program in Oral and Maxillofacial Pathology  and PhD Program in Oral and Experimental Pathology, Dental School, University of Maryland, Baltimore, USA
  • 2006-2008: Adjunct Associate Professor, Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, USA
  • 2006-2014: Assistant Professor, Dept. of Oral Pathology and Medicine, Section of Oral Pathology and Surgery, School of Dentistry, National and Kapodistrian University of Athens, Greece (tenured in 2010)
  • 2016: Visiting Scientist, Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, USA,
  • 2014-date: Associate Professor, Dept. of Oral Pathology and Medicine, Section of Oral Pathology and Surgery, School of Dentistry, National and Kapodistrian University of Athens, Greece

Participation in Theses and Dissertations

  • Postgraduate Program, Dental School, University of Maryland, Baltimore:
  • Supervisor in 1 postgraduate certificate thesis (completed); supervisor in 1 PhD dissertation (completed); member in 3 PhD advisory committees (completed)
  • Postgraduate Program, Dental School, University of Athens:
  • Supervisor in 5 M.Sc. theses (completed); supervisor in 3 PhD dissertations (1 completed and 2 ongoing); member in 7 PhD advisory committees (2 completed and 5 active)

Awards and Honours

  • NATO assistantship for postgraduate studies in Medical Sciences in USA, 1998-1999
  • Graduate Merit Award, Πανεπιστήμιο Maryland, Baltimore, USA, 1999
  • Member of the Honor Society of Phi Kappa Phi in recognition of academic excellence, 2002
  • Trainee award (PhD dissertation), Sixth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, McLean, Virginia, October 9-13, 2002
  • Trainee award (Postgraduate student Hessam Siavash), Sixth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, McLean, Virginia, October 9-13, 2002
  • Single Primary Investigator Designated Research Initiative Funds (DRIF) Award, Dental School, University of Maryland, Baltimore, 2003
  • Basic Science Award (Postgraduate student Hessam Siavash), Student Poster-Table Clinic Program, Student/Faculty Scholarship Day, Dental School, University of Maryland, Baltimore, MD, April 24, 2003
  • New Investigator Award, The University of Maryland Greenebaum Cancer Center Pilot Grant Program, 2004
  • Best Resident Basic Science Paper (Postgraduate student Hessam Siavash), 6th International Conference on Head and Neck Cancer, August 7-11, 2004, Washington, DC
  • Gorlin Award (Postgraduate student Mark Scheper), American Academy of Oral and Maxillofacial Pathology, 60th Annual Meeting and Continuing Education Program, San Antonio, TX, April 22–26, 2006
  • Award in Memory of Assoc. Prof. E. Angelopoulos (Postgraduate student Prokopis Argyris), 12th Scientific Student Meeting, Dental School, University of Athens, Greece, May 9-10, 2008
  • Hamilton B.G. Robinson Prize, Oral and Maxillofacial Pathology, Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 2009
  • First Prize for Best Poster Presentation (Postgraduate student Konstantinos Katoumas), 1st Panhellenic Meeting of Oral Pathology and Medicine, Athens, Greece, April 2-4, 2009
  • First Prize for Best Poster Presentation at postgraduate level (Postgraduate student Polyxeni Boziari), 29th Panhellenic Dental Congress, Ioannina, November 13-15, 2009
  • Young Scientist/Clinician Awards (Postgraduate student Konstantinos Katoumas), 10th Biennial Conference of European Association of Oral Medicine, London, September 21-25, 2010
  • Waldron Award, 65th Annual Meeting and Continuing Education Program of American Academy of Oral and Maxillofacial Pathology, San Juan, Puerto Rico, April 28–May 3, 2011
  • First Prize, Case Study Category (Postgraduate student Nikolaos Katsoulas), “Frontiers in Oral Medicine”, Orlando, Florida, USA, April 9-12, 2014
  • First Prize, Poster Category (Postgraduate student Ioannis Gkouveris), 12th Biennial Congress of European Association of Oral Medicine, Antalya, Turkey, 11-14 September 2014
  • Dental Student Travel Award (Postgraduate student Jason Tasoulas), Collaboration in Diagnostic Sciences, Annual Meeting of the American Academy of Oral and Maxillofacial Pathology, San Diego, CA, April 18-24, 2015
  • First Poster Award (Undergraduate students Andreas Tsolkas, Ioanna Tsouri, Basilis Notaras; Postgraduate student Argyrios Daskalopoulos), 14th Scientific Student Congress, Dental School of Athens, June 5-6, 2015
  • First Prize, Poster Presentation (Postgraduate student Argyrios Daskalopoulos),13th Biennial Congress of European Association of Oral Medicine, Turin, Italy, September 15-17, 2016
  • Second Prize, Oral Research Presentation, 13th Biennial Congress of European Association of Oral Medicine, Turin, Italy, 15-17 September 2016

Research Grants and Contracts

Principal Investigator

  • Silencing of suppressors of cytokine signaling (SOCS) in oral squamous cell carcinoma» [Designated Research Initiative Funds, Dental School, University of Maryland, Baltimore, 1/2003-12/2003]
  • Stat3-mediated downregulation of Survivin expression by COX inhibitors in oral squamous cell carcinoma» [The University of Maryland Greenebaum Cancer Center Pilot Grant Program, 10/2004-4/2006]
  • Investigation of expression, activation and interaction of signaling pathways MAPK and STAT3 in oral squamous cell carcinoma [ELKE, National and Kapodistrian University of Athens, 2008-2009]

Co-investigator

  • A novel serpin inhibitor of oral squamous carcinoma invasion [National Institute of Health/National Cancer Institute, USA, R01 DE12606, 1999-2008]
  • Cell marker and homing target for oral squamous carcinoma [National Institute of Health/National Cancer Institute, USA, R01 DE13118, 2000-2005]
  • Prognostic Markers in Trials for Head and Neck Cancer [National Institute of Health/National Cancer Institute, USA, R01 CA90328, 2005-2009]
  • The oncogenic role of STAT3 in oral squamous cell carcinoma [Irakleitos ΙΙ, ELKE, National and Kapodistrian University of Athens, 2011-2013]

Awards and Honours

  • NATO assistantship for postgraduate studies in Medical Sciences in USA, 1998-1999
  • Graduate Merit Award, Dental School, University of Maryland, Baltimore, USA, 1999
  • Member of the Honor Society of Phi Kappa Phi in recognition of academic excellence, 2002
  • Trainee award, Sixth Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer, McLean, Virginia, October 9-13, 2002
  • Single Primary Investigator Designated Research Initiative Funds (DRIF) Award, Dental School, University of Maryland, Baltimore, 2003
  • Basic science award (Postgraduate student Hessam Siavash), Student Poster-Table Clinic Program, Student/Faculty Scholarship Day, Dental School, University of Maryland, Baltimore, MD, April 24, 2003
  • New Investigator Award, The University of Maryland Greenebaum Cancer Center Pilot Grant Program, 2004
  • Best Resident Basic Science Paper (Postgraduate student Hessam Siavash), 6th International Conference on Head and Neck Cancer, August 7-11, 2004, Washington, DC
  • Gorlin Award (Postgraduate student Mark Scheper), American Academy of Oral and Maxillofacial Pathology, 60th Annual Meeting and Continuing Education Program, San Antonio, TX, April 22–26, 2006
  • Hamilton B.G. Robinson Prize,  for the best Oral and Maxillofacial Pathology scientific paper published in Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 2009
  • Young Scientist/Clinician Awards (Postgraduate student Konstantinos Katoumas), 10th Biennial Conference of European Association of Oral Medicine, London, September 21-25, 2010
  • Waldron Award, 65th Annual Meeting and Continuing Education Program of American Academy of Oral and Maxillofacial Pathology, San Juan, Puerto Rico, April 28–May 3, 201Membership in Scientific Societies

  • International Association for Dental Research (IADR) and Oral Medicine & Pathology Group, IADR (2000-2006, 2017-date)
  • American Association for Dental Research (AADR) (2002-2006)
  • American Academy of Oral and Maxillofacial Pathology (AAOMP) (Member: 2000-date, Fellow: 2001-date)
  • American Academy of Oral Medicine (AAOM) (Member: 2002-2010, Fellow: 2004-date)
  • European Association of Oral Medicine (EAOM) (Member: 2002-date, Secretary General: 2014-date)
  • North American Society for Head and Neck Pathology (NASHNP) (2002-2010)
  • American Association for Cancer Research (AACR) (2003-2006)
  • American Board of Oral and Maxillofacial Pathology (ABOMP) (2003-date)
  • American Dental Education Association (ADEA) (2004-2006)
  • Hellenic Association of Supportive Care of the Oral Cavity in Cancer (HASCOCC) (Founding Member: 2005)
  • Hellenic Society of Oral Medicine and Pathology (HSOMP) (Member: 2007-date, Treasurer: 2009-2015, President: 2015-date)
  • Hellenic Association for Molecular Cancer Research (HAMCR) (Founding Member: 2008-, Secretary General: 2008-2015, Vice President: 2015-date)

Selected publications in scientific journals

  • Schumaker L, Nikitakis N, Goloubeva O, Tan M, Taylor R, Cullen KJ. Elevated expression of glutathione S-transferase pi and p53 confers poor prognosis in head and neck cancer patients treated with chemoradiotherapy but not radiotherapy alone. Clin Cancer Res. 2008;14:5877-83.
  • Nikitakis NG, Scheper MA, Papanikolaou VS, Sauk JJ. The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:826-36.
  • Nikitakis NG, Scheper MA, Papanikolaou VS, Sklavounou A, Sauk JJ. Immunohistochemical expression of the oncogenic molecules active Stat3 and survivin in benign and malignant salivary gland tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:837-43.
  • Cullen KJ, Schumaker L, Nikitakis N, Sarlis NJ, Tan M, Goloubeva O, Haddad RI, Posner MR. beta-Tubulin-II expression strongly predicts outcome in patients receiving induction chemotherapy for locally advanced squamous carcinoma of the head and neck: a companion analysis of the TAX 324 Trial. J Clin Oncol. 2009;27:6222-8.
  • Sauk JJ, Nikitakis NG, Scheper MA. Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:68-78.
  • Wen J, Nikitakis NG, Chaisuparat R, Greenwell-Wild T, Gliozzi M, Jin W, Adli A, Moutsopoulos N, Wu T, Warburton G, Wahl SM. Secretory Leukocyte Protease Inhibitor (SLPI) Expression and Tumor Invasion in Oral Squamous Cell Carcinoma. Am J Pathol. 2011;178:2866-78.
  • Wu Y, Posner MR, Schumaker LM, Nikitakis N, Goloubeva O, Tan M, Lu C, Iqbal S, Lorch J, Sarlis NJ, Haddad RI, Cullen KJ. Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer: An analysis of the TAX 324 trial. Cancer. 2012;118:1811-7.
  • Nikitakis NG, Polymeri A , Polymeris A , Sklavounou A . Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review. Head Neck Pathol. 2012;6:216-23.
  • Piperi E , Tosios KI , Nikitakis NG, Kyriakopoulos VF , Tzerbos F , Koutlas IG , Sklavounou A . Well-Differentiated Liposarcoma/Atypical Lipomatous Tumor of the Oral Cavity: Report of Three Cases and Review of the Literature. Head Neck Pathol. 2012;6:354-63.
  • Nikitakis NG, Polyzois G, Katoumas K, Titsinides S, Zolota V, Sklavounou A, Papadas T. Extranodal nasal type NK/T cell lymphoma of the palate and paranasal sinuses. Am J Case Rep. 2012:13;79-85.
  • Karathanasi V, Tosios KI, Nikitakis NG, Piperi E, Koutlas I, Trimis G, Sklavounou A.TGF-β1, Smad-2/-3, Smad-1/-5/-8, and Smad-4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study. J Oral Pathol Med. 2012 Nov 15. doi: 10.1111/jop.12016. [Epub ahead of print]

Areas of scientific interest

  • Oral Squamous Cell Carcinoma and Potentially Malignant Disorders: Immunohistochemical and molecular markers; cancer cell proliferation and apoptosis; cell signaling pathways; angiogenesis; novel antineoplastic strategies and molecular targets
  • Salivary Gland, Soft Tissue and Odontogenic Tumors: Clinicopathologic characterization and immunohistochemical analysis
  • Non-neoplastic diseases and conditions of the oral and maxillofacial region: diagnosis and management (e.g. immunologically-mediated diseases, oral manifestations of systemic diseases, burning mouth syndrome)

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